Alcaftadine
An antihistamine eye drop that blocks histamine receptors in the eye and also stabilizes mast cells to prevent the release of allergy-triggering chemicals, providing rapid and sustained relief from itchy, allergic eyes. It is specifically formulated for the conjunctiva and works effectively to reduce redness, itching, and watering associated with allergic conjunctivitis.
分子量
307.4000 g/mol
LogP
1.70
TPSA
38.10 Ų
Lipinski 五规则
符合
作用机制
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
二维结构
Cite this structure
Embed this structure
SMILES
CN1CCC(=C2c3ccccc3CCn3c(C=O)cnc32)CC1
InChI
InChI=1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3
Molecular Formula
C19H21N3O
HBD / HBA
- / 3
可旋转键数
1
重原子数
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
An antihistamine eye drop that blocks histamine receptors in the eye and also stabilizes mast cells to prevent the release of allergy-triggering chemicals, providing rapid and sustained relief from itchy, allergic eyes. It is specifically formulated for the conjunctiva and works effectively to reduce redness, itching, and watering associated with allergic conjunctivitis.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Alcaftadine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201747. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 19371515. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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