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Alendronate Sodium

CHEMBL675 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
325.1 g/mol
LogP
—
Phase
4

The sodium salt form of alendronic acid, a bisphosphonate medication that prevents bone breakdown by inhibiting osteoclast cells responsible for bone resorption. It is widely used to treat and prevent osteoporosis in postmenopausal women and men, and to treat Paget's disease of bone, significantly reducing the risk of fractures.

分子量

325.1200 g/mol

TPSA

167.00 Ų

治疗领域

Ovarian Cancer Thyroid Cancer Rheumatoid Arthritis Osteoporosis Asthma Breast Cancer HIV/AIDS Prostate Cancer

作用机制

Binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption by disrupting the mevalonate pathway within osteoclasts. This reduces bone turnover and increases bone mineral density.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption by disrupting the mevalonate pathway within osteoclasts. This reduces bone turnover and increases bone mineral density.

二维结构

SVG PNG

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SMILES

                    
NCCCC(O)(P(=O)([O-])O)P(=O)(O)O.[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C4H13NO7P2.Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);/q;+1/p-1

                

                

                

                    
                    

                        
Molecular Formula

                        
C4H18NNaO10P2

                    

                    
                    

                        
HBD / HBA

                        
8 / 11

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
The sodium salt form of alendronic acid, a bisphosphonate medication that prevents bone breakdown by inhibiting osteoclast cells responsible for bone resorption. It is widely used to treat and prevent osteoporosis in postmenopausal women and men, and to treat Paget's disease of bone, significantly reducing the risk of fractures.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Binds to hydroxyapatite crystals in bone, inhibiting osteoclast-mediated bone resorption by disrupting the mevalonate pathway within osteoclasts. This reduces bone turnover and increases bone mineral density.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Alendronate Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL675.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 23681107.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.