Allogeneic T Cells Genetically Modified With A Retroviral Vector Encoding For A Truncated Form Of The Human Low Affinity Nerve Growth Factor Receptor (Deltalngfr) And The Herpes Simplex I Virus Thymidine Kinase (Hsv-Tk Mut2)
These are donor T cells genetically engineered to carry a built-in safety switch in the form of the herpes simplex virus thymidine kinase gene, which makes the cells vulnerable to the antiviral drug ganciclovir if they need to be eliminated. This approach allows the therapeutic immune cells to be safely destroyed if they cause unacceptable side effects such as graft-versus-host disease after transplantation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
These are donor T cells genetically engineered to carry a built-in safety switch in the form of the herpes simplex virus thymidine kinase gene, which makes the cells vulnerable to the antiviral drug ganciclovir if they need to be eliminated. This approach allows the therapeutic immune cells to be safely destroyed if they cause unacceptable side effects such as graft-versus-host disease after transplantation.
Yes, Allogeneic T Cells Genetically Modified With A Retroviral Vector Encoding For A Truncated Form Of The Human Low Affinity Nerve Growth Factor Receptor (Deltalngfr) And The Herpes Simplex I Virus Thymidine Kinase (Hsv-Tk Mut2) is an approved drug. It has reached clinical phase 4. It is classified as a Unknown.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5315097. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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