Antihemophilic Factor, Pegylated (Mw 20000) Human Sequence Recombinant
A recombinant form of clotting Factor VIII that has been chemically modified with polyethylene glycol to extend its time in circulation, reducing the frequency of injections needed. It is used to prevent and treat bleeding episodes in people with hemophilia A.
分子量
508.6000 g/mol
LogP
-3.60
TPSA
197.00 Ų
Lipinski 五规则
不符合
作用机制
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
二维结构
Cite this structure
Embed this structure
SMILES
COCCNC(=O)OCC(COC(=O)NCCOC)OCCCC(=O)NCCCC[C@@H](C(=O)O)N
InChI
InChI=1S/C21H40N4O10/c1-31-12-9-24-20(29)34-14-16(15-35-21(30)25-10-13-32-2)33-11-5-7-18(26)23-8-4-3-6-17(22)19(27)28/h16-17H,3-15,22H2,1-2H3,(H,23,26)(H,24,29)(H,25,30)(H,27,28)/t17-/m0/s1
Molecular Formula
C21H40N4O10
HBD / HBA
5 / 11
可旋转键数
23
重原子数
35
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A recombinant form of clotting Factor VIII that has been chemically modified with polyethylene glycol to extend its time in circulation, reducing the frequency of injections needed. It is used to prevent and treat bleeding episodes in people with hemophilia A.
As a recombinant protein, it replicates the function of the naturally occurring human protein, supplementing or replacing deficient endogenous production to restore normal physiological activity.
Yes, Antihemophilic Factor, Pegylated (Mw 20000) Human Sequence Recombinant is an approved drug. It has reached clinical phase 4. It is classified as a Unknown.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4594584. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 86278357. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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