Apalutamide

CHEMBL3183409 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

477.4 g/mol

LogP

3.0

Phase

4

A next-generation androgen receptor inhibitor that blocks the effects of testosterone and other male hormones on prostate cancer cells, slowing their growth and spread. It is approved for non-metastatic and metastatic castration-resistant prostate cancer.

分子量

477.4000 g/mol

LogP

3.00

TPSA

121.00 Å²

Lipinski 五规则

符合

治疗领域

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Breast Cancer Prostate Cancer Colorectal Cancer

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

CNC(=O)c1ccc(N2C(=S)N(c3cnc(C#N)c(C(F)(F)F)c3)C(=O)C23CCC3)cc1F

InChI

InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

Molecular Formula

C21H15F4N5O2S

HBD / HBA

1 / 9

可旋转键数

3

重原子数

33

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A next-generation androgen receptor inhibitor that blocks the effects of testosterone and other male hormones on prostate cancer cells, slowing their growth and spread. It is approved for non-metastatic and metastatic castration-resistant prostate cancer.

Yes, Apalutamide is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3183409. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 24872560. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C21H15F4N5O2S
同义词: 1

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.