Apremilast

CHEMBL514800 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

460.5 g/mol

LogP

1.8

Phase

4

A phosphodiesterase-4 inhibitor that reduces the production of inflammatory molecules inside immune cells, calming inflammation in conditions such as psoriasis and psoriatic arthritis. It is taken by mouth and is an option for patients who cannot use or have not responded to other treatments.

分子量

460.5000 g/mol

LogP

1.80

TPSA

127.00 Å²

Lipinski 五规则

符合

治疗领域

Rheumatoid Arthritis Psoriasis Systemic Lupus Erythematosus Atopic Dermatitis Gout Cardiovascular Disease

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC

InChI

InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1

Molecular Formula

C22H24N2O7S

HBD / HBA

1 / 7

可旋转键数

8

重原子数

32

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A phosphodiesterase-4 inhibitor that reduces the production of inflammatory molecules inside immune cells, calming inflammation in conditions such as psoriasis and psoriatic arthritis. It is taken by mouth and is an option for patients who cannot use or have not responded to other treatments.

Yes, Apremilast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL514800. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 11561674. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C22H24N2O7S
同义词: 1

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.