Avibactam
A beta-lactamase inhibitor that inactivates enzymes produced by resistant bacteria that would otherwise destroy cephalosporin and other beta-lactam antibiotics. It is always used in combination with a partner antibiotic to restore activity against carbapenem-resistant organisms.
分子量
265.2500 g/mol
LogP
-1.80
TPSA
139.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing transpeptidation and cross-linking of peptidoglycan chains. This weakens the bacterial cell wall, leading to osmotic lysis and cell death.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing transpeptidation and cross-linking of peptidoglycan chains. This weakens the bacterial cell wall, leading to osmotic lysis and cell …
二维结构
Cite this structure
Embed this structure
SMILES
NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O
InChI
InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1
Molecular Formula
C7H11N3O6S
HBD / HBA
2 / 6
可旋转键数
3
重原子数
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A beta-lactamase inhibitor that inactivates enzymes produced by resistant bacteria that would otherwise destroy cephalosporin and other beta-lactam antibiotics. It is always used in combination with a partner antibiotic to restore activity against carbapenem-resistant organisms.
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), preventing transpeptidation and cross-linking of peptidoglycan chains. This weakens the bacterial cell wall, leading to osmotic lysis and cell death.
Yes, Avibactam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1689063. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9835049. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
Embed This Widget
Add the script tag and a data attribute to embed this widget.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<div data-drugfyi="drug" data-slug="avibactam"></div>Embed via iframe for maximum compatibility.
<iframe src="https://drugfyi.com/iframe/drug/avibactam/" width="420" height="400" frameborder="0" style="border:0;border-radius:10px;max-width:100%" loading="lazy"></iframe>Paste this URL in WordPress, Medium, or any oEmbed-compatible platform.
https://drugfyi.com/drug/avibactam/Add a dynamic SVG badge to your README or docs.
[](https://drugfyi.com/drug/avibactam/)Use the native HTML custom element.
<script src="https://cdn.jsdelivr.net/npm/drugfyi-embed@1/dist/embed.min.js" defer></script>
<drugfyi-drug slug="avibactam"></drugfyi-drug>