Axitinib

CHEMBL1289926 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

386.5 g/mol

LogP

4.2

Phase

4

A potent inhibitor of vascular endothelial growth factor receptors that cuts off the blood supply that tumors need to grow, used for renal cell carcinoma. It is taken by mouth and can cause high blood pressure as a common side effect.

分子量

386.5000 g/mol

LogP

4.20

TPSA

96.00 Å²

Lipinski 五规则

符合

治疗领域

Melanoma Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Age-Related Macular Degeneration Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1

InChI

InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+

Molecular Formula

C22H18N4OS

HBD / HBA

2 / 4

可旋转键数

5

重原子数

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A potent inhibitor of vascular endothelial growth factor receptors that cuts off the blood supply that tumors need to grow, used for renal cell carcinoma. It is taken by mouth and can cause high blood pressure as a common side effect.

Yes, Axitinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1289926. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 6450551. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C22H18N4OS
同义词: 1

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.