Berotralstat Hydrochloride

CHEMBL6067995 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

635.5 g/mol

LogP

—

Phase

4

The hydrochloride salt form of berotralstat, used for long-term prevention of hereditary angioedema attacks. It inhibits the enzyme plasma kallikrein to reduce the frequency and severity of swelling episodes affecting the skin, gut, and airways. It is taken orally on a daily basis.

分子量

635.5000 g/mol

TPSA

109.00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

Cl.Cl.N#Cc1cccc([C@@H](NCC2CC2)c2ccc(F)c(NC(=O)c3cc(C(F)(F)F)nn3-c3cccc(CN)c3)c2)c1

InChI

InChI=1S/C30H26F4N6O.2ClH/c31-24-10-9-22(28(37-17-18-7-8-18)21-5-1-3-19(11-21)15-35)13-25(24)38-29(41)26-14-27(30(32,33)34)39-40(26)23-6-2-4-20(12-23)16-36;;/h1-6,9-14,18,28,37H,7-8,16-17,36H2,(H,38,41);2*1H/t28-;;/m1../s1

Molecular Formula

C30H28Cl2F4N6O

HBD / HBA

5 / 9

可旋转键数

9

重原子数

43

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

The hydrochloride salt form of berotralstat, used for long-term prevention of hereditary angioedema attacks. It inhibits the enzyme plasma kallikrein to reduce the frequency and severity of swelling episodes affecting the skin, gut, and airways. It is taken orally on a daily basis.

Yes, Berotralstat Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL6067995. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 139030242. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C30H28Cl2F4N6O
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.