Berotralstat

CHEMBL5189739 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

562.6 g/mol

LogP

4.5

Phase

4

An oral medication used to prevent recurrent attacks of hereditary angioedema, a rare condition causing episodes of severe swelling. It works by inhibiting plasma kallikrein, an enzyme responsible for triggering the swelling episodes. Unlike injectable treatments, its oral administration offers convenience for long-term prevention.

分子量

562.6000 g/mol

LogP

4.50

TPSA

109.00 Å²

Lipinski 五规则

符合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

N#Cc1cccc([C@@H](NCC2CC2)c2ccc(F)c(NC(=O)c3cc(C(F)(F)F)nn3-c3cccc(CN)c3)c2)c1

InChI

InChI=1S/C30H26F4N6O/c31-24-10-9-22(28(37-17-18-7-8-18)21-5-1-3-19(11-21)15-35)13-25(24)38-29(41)26-14-27(30(32,33)34)39-40(26)23-6-2-4-20(12-23)16-36/h1-6,9-14,18,28,37H,7-8,16-17,36H2,(H,38,41)/t28-/m1/s1

Molecular Formula

C30H26F4N6O

HBD / HBA

3 / 9

可旋转键数

9

重原子数

41

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

An oral medication used to prevent recurrent attacks of hereditary angioedema, a rare condition causing episodes of severe swelling. It works by inhibiting plasma kallikrein, an enzyme responsible for triggering the swelling episodes. Unlike injectable treatments, its oral administration offers convenience for long-term prevention.

Yes, Berotralstat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL5189739. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 137528262. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C30H26F4N6O
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.