Bismuth Subcitrate Potassium

Eradication regimens for Helicobacter pylori often include a bismuth salt, and bismuth subcitrate potassium serves that role in quadruple therapy. Bismuth compounds deposit a protective layer over ulcerated gastric mucosa and exert direct antimicrobial activity against H. pylori, an effect independent of the antibiotics given alongside them. Because the bismuth component acts by a mechanism unrelated to antibacterial resistance pathways, it retains usefulness where resistance has narrowed the options. Treatment therefore pairs it with antibacterial agents and acid suppression rather than using it alone. The salt is recorded with the formula C12H8BiK5O14 and a formula mass near 780.7 g/mol, and it is an approved agent developed through the final clinical phase.

SMILES

C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])[O-].C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])[O-].[K+].[K+].[K+].[K+].[K+].[Bi+3]

InChI

InChI=1S/2C6H7O7.Bi.5K/c2*7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;;/h2*1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;;;/q2*-1;+3;5*+1/p-6