Brompheniramine
A first-generation antihistamine used to relieve symptoms of allergic rhinitis, hay fever, and the common cold, including sneezing, runny nose, and itching. It blocks histamine H1 receptors and has mild sedative and anticholinergic properties. It is commonly found in combination cold and allergy products.
分子量
319.2400 g/mol
LogP
3.50
TPSA
16.10 Ų
Lipinski 五规则
符合
作用机制
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
二维结构
Cite this structure
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SMILES
CN(C)CCC(c1ccc(Br)cc1)c1ccccn1
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
Molecular Formula
C16H19BrN2
HBD / HBA
- / 2
可旋转键数
5
重原子数
19
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A first-generation antihistamine used to relieve symptoms of allergic rhinitis, hay fever, and the common cold, including sneezing, runny nose, and itching. It blocks histamine H1 receptors and has mild sedative and anticholinergic properties. It is commonly found in combination cold and allergy products.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Brompheniramine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL811. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6834. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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