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Bupivacaine Hydrochloride

CHEMBL1200396 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
324.9 g/mol
LogP
—
Phase
4

The hydrochloride salt form of bupivacaine, the most commonly used formulation of this long-acting local anesthetic. It is injected to block pain in specific regions of the body during and after surgical procedures, including labor. Its cardiac toxicity risk demands careful attention to total dose and accidental intravascular injection.

分子量

324.9000 g/mol

TPSA

32.30 Ų

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Benign Prostatic Hyperplasia Cardiovascular Disease Pain Management Ophthalmology Non-Small Cell Lung Cancer Osteoporosis Alzheimer's Disease Migraine Melanoma Inflammatory Bowel Disease Obstetrics & Gynecology Obesity Breast Cancer Chronic Pain Atrial Fibrillation Prostate Cancer Colorectal Cancer

作用机制

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C.Cl

                

                

                
                

                    
InChI

                    
InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H

                

                

                

                    
                    

                        
Molecular Formula

                        
C18H29ClN2O

                    

                    
                    

                        
HBD / HBA

                        
2 / 2

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
22

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
The hydrochloride salt form of bupivacaine, the most commonly used formulation of this long-acting local anesthetic. It is injected to block pain in specific regions of the body during and after surgical procedures, including labor. Its cardiac toxicity risk demands careful attention to total dose and accidental intravascular injection.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Bupivacaine Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200396.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 64737.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.