Capivasertib
A kinase inhibitor that targets AKT, a key protein in the PI3K signaling pathway frequently activated in breast and other cancers. It is used in combination with fulvestrant to treat hormone receptor-positive, HER2-negative breast cancer with specific PI3K pathway mutations following disease progression. It works by blocking cellular survival and growth signals downstream of PI3K.
分子量
428.9000 g/mol
LogP
1.70
TPSA
120.00 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Targets the HER2 (ErbB2) receptor tyrosine kinase, blocking HER2-mediated signaling that drives proliferation in HER2-overexpressing cancer cells.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Targets the HER2 (ErbB2) receptor tyrosine kinase, blocking HER2-mediated signaling that drives proliferation in HER2-overexpressing cancer cells.
二维结构
Cite this structure
Embed this structure
SMILES
NC1(C(=O)N[C@@H](CCO)c2ccc(Cl)cc2)CCN(c2nc[nH]c3nccc2-3)CC1
InChI
InChI=1S/C21H25ClN6O2/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26)/t17-/m0/s1
Molecular Formula
C21H25ClN6O2
HBD / HBA
4 / 6
可旋转键数
6
重原子数
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A kinase inhibitor that targets AKT, a key protein in the PI3K signaling pathway frequently activated in breast and other cancers. It is used in combination with fulvestrant to treat hormone receptor-positive, HER2-negative breast cancer with specific PI3K pathway mutations following disease progression. It works by blocking cellular survival and growth signals downstream of PI3K.
Targets the HER2 (ErbB2) receptor tyrosine kinase, blocking HER2-mediated signaling that drives proliferation in HER2-overexpressing cancer cells.
Yes, Capivasertib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2325741. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 25227436. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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