Cariprazine

CHEMBL2028019 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

427.4 g/mol

LogP

4.3

Phase

4

An atypical antipsychotic that acts as a partial agonist at dopamine D2 and D3 receptors as well as serotonin 5-HT1A receptors. It is approved for the treatment of schizophrenia and acute manic or mixed episodes associated with bipolar I disorder. Its relatively high affinity for D3 receptors is thought to contribute to its effects on mood and cognition.

分子量

427.4000 g/mol

LogP

4.30

TPSA

38.80 Å²

Lipinski 五规则

符合

治疗领域

Schizophrenia Bipolar Disorder Generalized Anxiety Disorder Stroke Major Depressive Disorder

作用机制

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal …

二维结构

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SMILES

CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1

InChI

InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)/t16-,17-

Molecular Formula

C21H32Cl2N4O

HBD / HBA

1 / 3

可旋转键数

5

重原子数

28

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

An atypical antipsychotic that acts as a partial agonist at dopamine D2 and D3 receptors as well as serotonin 5-HT1A receptors. It is approved for the treatment of schizophrenia and acute manic or mixed episodes associated with bipolar I disorder. Its relatively high affinity for D3 receptors is thought to contribute to its effects on mood and cognition.

Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.

Yes, Cariprazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2028019. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 11154555. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C21H32Cl2N4O
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.