Carmustine
An alkylating chemotherapy agent belonging to the nitrosourea class that works by crosslinking DNA and disrupting RNA synthesis, killing rapidly dividing cancer cells. It is used to treat brain tumors, multiple myeloma, Hodgkin's and non-Hodgkin's lymphomas. Significant bone marrow suppression and pulmonary toxicity are important concerns during therapy.
分子量
214.0500 g/mol
LogP
1.50
TPSA
61.80 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
O=NN(CCCl)C(=O)NCCCl
InChI
InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
Molecular Formula
C5H9Cl2N3O2
HBD / HBA
1 / 3
可旋转键数
4
重原子数
12
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
An alkylating chemotherapy agent belonging to the nitrosourea class that works by crosslinking DNA and disrupting RNA synthesis, killing rapidly dividing cancer cells. It is used to treat brain tumors, multiple myeloma, Hodgkin's and non-Hodgkin's lymphomas. Significant bone marrow suppression and pulmonary toxicity are important concerns during therapy.
Yes, Carmustine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL513. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 2578. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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