Cefotiam Hydrochloride
The hydrochloride salt form of cefotiam is used for parenteral administration in treating susceptible bacterial infections. It retains the second-generation cephalosporin spectrum without the coagulation-interfering side chain of some related antibiotics. It remains in use mainly in Asian and European countries.
分子量
598.6000 g/mol
TPSA
251.00 Ų
作用机制
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
二维结构
Cite this structure
Embed this structure
SMILES
CN(C)CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3csc(N)n3)[C@H]2SC1.Cl.Cl
InChI
InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1
Molecular Formula
C18H25Cl2N9O4S3
HBD / HBA
5 / 13
可旋转键数
10
重原子数
36
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
The hydrochloride salt form of cefotiam is used for parenteral administration in treating susceptible bacterial infections. It retains the second-generation cephalosporin spectrum without the coagulation-interfering side chain of some related antibiotics. It remains in use mainly in Asian and European countries.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cefotiam Hydrochloride is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL4303232. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 47896. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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