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Ceftazidime

CHEMBL44354 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
546.6 g/mol
LogP
0.4
Phase
4

A third-generation parenteral cephalosporin antibiotic with potent activity against Pseudomonas aeruginosa and other gram-negative pathogens, used for serious hospital-acquired infections including pneumonia, bacteremia, and meningitis. It is a cornerstone antibiotic in treating gram-negative infections in immunocompromised patients. Resistance can emerge, and susceptibility testing is recommended.

分子量

546.6000 g/mol

LogP

0.40

TPSA

245.00 Ų

Lipinski 五规则

不符合

治疗领域

Pain Management Asthma Chronic Obstructive Pulmonary Disease Insomnia Infectious Disease Lymphoma Hypertension Chronic Pain Heart Failure Leukemia

作用机制

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

二维结构

SVG PNG

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SMILES

                    
CC(C)(O/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccccc3)CS[C@H]12)c1csc(N)n1)C(=O)O

                

                

                
                

                    
InChI

                    
InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H22N6O7S2

                    

                    
                    

                        
HBD / HBA

                        
3 / 12

                    

                    
                    

                        
可旋转键数

                        
8

                    

                    
                    
                    

                        
重原子数

                        
37

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A third-generation parenteral cephalosporin antibiotic with potent activity against Pseudomonas aeruginosa and other gram-negative pathogens, used for serious hospital-acquired infections including pneumonia, bacteremia, and meningitis. It is a cornerstone antibiotic in treating gram-negative infections in immunocompromised patients. Resistance can emerge, and susceptibility testing is recommended.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Ceftazidime is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL44354.
                Open-access bioactivity database.
            
        
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  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 5481173.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.