Cephapirin Sodium
The sodium salt form of cephapirin was used parenterally for gram-positive bacterial infections and surgical prophylaxis in human medicine. As an early first-generation cephalosporin, it has been replaced by more modern agents. It remains available in some veterinary formulations for mastitis treatment in cattle.
分子量
445.4000 g/mol
TPSA
179.00 Ų
作用机制
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
二维结构
Cite this structure
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SMILES
CC(=O)OCC1=C(C(=O)[O-])N2C(=O)[C@@H](NC(=O)CSc3ccncc3)[C@H]2SC1.[Na+]
InChI
InChI=1S/C17H17N3O6S2.Na/c1-9(21)26-6-10-7-28-16-13(15(23)20(16)14(10)17(24)25)19-12(22)8-27-11-2-4-18-5-3-11;/h2-5,13,16H,6-8H2,1H3,(H,19,22)(H,24,25);/q;+1/p-1/t13-,16-;/m1./s1
Molecular Formula
C17H16N3NaO6S2
HBD / HBA
1 / 9
可旋转键数
8
重原子数
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
The sodium salt form of cephapirin was used parenterally for gram-positive bacterial infections and surgical prophylaxis in human medicine. As an early first-generation cephalosporin, it has been replaced by more modern agents. It remains available in some veterinary formulations for mastitis treatment in cattle.
Disrupts bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), inhibiting the final transpeptidation step of peptidoglycan synthesis. The resulting cell wall defects cause osmotic instability and bacteriolysis.
Yes, Cephapirin Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201043. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 23675312. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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