Cetuximab
A monoclonal antibody that targets and blocks the epidermal growth factor receptor (EGFR), inhibiting downstream signaling that promotes cancer cell proliferation and survival. It is used to treat EGFR-expressing colorectal cancer (in patients without RAS mutations) and squamous cell carcinoma of the head and neck. Infusion reactions and acneiform skin rash are characteristic adverse effects.
治疗领域
作用机制
Binds to a specific target antigen on tumor cells or immune cells, triggering immune-mediated destruction through antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), or direct signaling inhibition.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Binds to a specific target antigen on tumor cells or immune cells, triggering immune-mediated destruction through antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), or direct signaling inhibition.
HBD / HBA
- / -
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A monoclonal antibody that targets and blocks the epidermal growth factor receptor (EGFR), inhibiting downstream signaling that promotes cancer cell proliferation and survival. It is used to treat EGFR-expressing colorectal cancer (in patients without RAS mutations) and squamous cell carcinoma of the head and neck. Infusion reactions and acneiform skin rash are characteristic adverse effects.
Binds to a specific target antigen on tumor cells or immune cells, triggering immune-mediated destruction through antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), or direct signaling inhibition.
Yes, Cetuximab is an approved drug. It has reached clinical phase 4. It is classified as a Antibody.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201577. Open-access bioactivity database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-02-27.
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