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Chlorothiazide Sodium

CHEMBL1200616 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
317.7 g/mol
LogP
—
Phase
4

The sodium salt formulation of chlorothiazide allows for intravenous administration in patients unable to take oral diuretics. It shares the thiazide diuretic mechanism and indications of the oral form. Electrolyte monitoring is essential, particularly for potassium and sodium levels during therapy.

分子量

317.7000 g/mol

TPSA

124.00 Ų

治疗领域

Cardiovascular Disease Pain Management Generalized Anxiety Disorder Melanoma Chronic Kidney Disease Stroke Hyperlipidemia Obesity Type 2 Diabetes Hypertension Chronic Pain Heart Failure Atrial Fibrillation

作用机制

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
NS(=O)(=O)c1cc2c(cc1Cl)N=C[N-]S2(=O)=O.[Na+]

                

                

                
                

                    
InChI

                    
InChI=1S/C7H5ClN3O4S2.Na/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5;/h1-3H,(H2-,9,10,11,12,13);/q-1;+1

                

                

                

                    
                    

                        
Molecular Formula

                        
C7H5ClN3NaO4S2

                    

                    
                    

                        
HBD / HBA

                        
1 / 7

                    

                    
                    

                        
可旋转键数

                        
1

                    

                    
                    
                    

                        
重原子数

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
The sodium salt formulation of chlorothiazide allows for intravenous administration in patients unable to take oral diuretics. It shares the thiazide diuretic mechanism and indications of the oral form. Electrolyte monitoring is essential, particularly for potassium and sodium levels during therapy.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits sodium reabsorption in the renal tubules, promoting excretion of sodium, chloride, and water. This reduces extracellular fluid volume and cardiac preload, lowering blood pressure.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Chlorothiazide Sodium is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1200616.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 23675744.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.