Clascoterone
A topical androgen receptor inhibitor that blocks the effects of dihydrotestosterone and other androgens in sebaceous glands and hair follicles, reducing sebum production and inflammation in acne-prone skin. It is applied directly to affected areas and has minimal systemic absorption, reducing the risk of systemic anti-androgenic effects. It is approved for the topical treatment of acne vulgaris in patients aged 12 and older.
分子量
402.5000 g/mol
LogP
3.90
TPSA
80.70 Ų
Lipinski 五规则
符合
作用机制
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
二维结构
Cite this structure
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SMILES
CCC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C
InChI
InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1
Molecular Formula
C24H34O5
HBD / HBA
1 / 5
可旋转键数
5
重原子数
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A topical androgen receptor inhibitor that blocks the effects of dihydrotestosterone and other androgens in sebaceous glands and hair follicles, reducing sebum production and inflammation in acne-prone skin. It is applied directly to affected areas and has minimal systemic absorption, reducing the risk of systemic anti-androgenic effects. It is approved for the topical treatment of acne vulgaris in patients aged 12 and older.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Clascoterone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3590187. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 11750009. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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