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Clotrimazole

CHEMBL104 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
344.8 g/mol
LogP
5.0
Phase
4

A broad-spectrum azole antifungal that disrupts fungal cell membranes by inhibiting ergosterol synthesis, used to treat athlete's foot, vaginal yeast infections, and oral thrush. It is available as creams, lozenges, and vaginal suppositories.

分子量

344.8000 g/mol

LogP

5.00

TPSA

17.80 Ų

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Endometriosis Non-Small Cell Lung Cancer Inflammatory Bowel Disease Chronic Kidney Disease Lymphoma Breast Cancer Atopic Dermatitis HIV/AIDS Heart Failure Prostate Cancer Colorectal Cancer Leukemia

作用机制

Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1

                

                

                
                

                    
InChI

                    
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

                

                

                

                    
                    

                        
Molecular Formula

                        
C22H17ClN2

                    

                    
                    

                        
HBD / HBA

                        
- / 1

                    

                    
                    

                        
可旋转键数

                        
4

                    

                    
                    
                    

                        
重原子数

                        
25

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A broad-spectrum azole antifungal that disrupts fungal cell membranes by inhibiting ergosterol synthesis, used to treat athlete's foot, vaginal yeast infections, and oral thrush. It is available as creams, lozenges, and vaginal suppositories.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits the fungal cytochrome P450 enzyme lanosterol 14-alpha-demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Clotrimazole is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL104.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 2812.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.