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Dexketoprofen

CHEMBL75435 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
254.3 g/mol
LogP
3.1
Phase
4

The pharmacologically active S-enantiomer of the NSAID ketoprofen, used for short-term treatment of mild-to-moderate pain including musculoskeletal conditions, dysmenorrhea, and dental pain. Isolating the active enantiomer may provide an improved side-effect profile at lower doses.

分子量

254.2800 g/mol

LogP

3.10

TPSA

54.40 Ų

Lipinski 五规则

符合

治疗领域

Pancreatic Cancer Pain Management Non-Small Cell Lung Cancer Parkinson's Disease Migraine Generalized Anxiety Disorder Obesity Breast Cancer Chronic Pain Prostate Cancer

作用机制

Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.

二维结构

SVG PNG

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SMILES

                    
C[C@H](C(=O)O)c1cccc(C(=O)c2ccccc2)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H14O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
可旋转键数

                        
4

                    

                    
                    
                    

                        
重原子数

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
The pharmacologically active S-enantiomer of the NSAID ketoprofen, used for short-term treatment of mild-to-moderate pain including musculoskeletal conditions, dysmenorrhea, and dental pain. Isolating the active enantiomer may provide an improved side-effect profile at lower doses.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits cyclooxygenase (COX-1 and/or COX-2) enzymes, reducing the synthesis of prostaglandins and thromboxanes from arachidonic acid. This produces anti-inflammatory, analgesic, and antipyretic effects.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Dexketoprofen is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL75435.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 667550.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.