Didanosine
A nucleoside reverse transcriptase inhibitor (NRTI) used as part of combination antiretroviral therapy for HIV infection by blocking the viral enzyme reverse transcriptase needed to make copies of the virus. It must be taken on an empty stomach for adequate absorption. Serious risks include pancreatitis and peripheral neuropathy, and it should not be combined with certain other antivirals.
分子量
236.2300 g/mol
LogP
-1.20
TPSA
88.70 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.
二维结构
Cite this structure
Embed this structure
SMILES
O=c1[nH]cnc2c1ncn2[C@H]1CC[C@@H](CO)O1
InChI
InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
Molecular Formula
C10H12N4O3
HBD / HBA
2 / 5
可旋转键数
2
重原子数
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A nucleoside reverse transcriptase inhibitor (NRTI) used as part of combination antiretroviral therapy for HIV infection by blocking the viral enzyme reverse transcriptase needed to make copies of the virus. It must be taken on an empty stomach for adequate absorption. Serious risks include pancreatitis and peripheral neuropathy, and it should not be combined with certain other antivirals.
Incorporated into viral DNA by reverse transcriptase as a nucleoside analog, causing chain termination and inhibition of viral replication.
Yes, Didanosine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1460. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135398739. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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