Ethopropazine
This phenothiazine medication blocks certain receptors in the nervous system and has anticholinergic properties that help relieve muscle stiffness and tremor in Parkinson's disease. It also has some antihistamine activity.
分子量
312.5000 g/mol
LogP
4.80
TPSA
31.80 Ų
Lipinski 五规则
符合
作用机制
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
二维结构
Cite this structure
Embed this structure
SMILES
CCN(CC)C(C)CN1c2ccccc2Sc2ccccc21
InChI
InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
Molecular Formula
C19H24N2S
HBD / HBA
- / 3
可旋转键数
5
重原子数
22
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This phenothiazine medication blocks certain receptors in the nervous system and has anticholinergic properties that help relieve muscle stiffness and tremor in Parkinson's disease. It also has some antihistamine activity.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Ethopropazine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1206. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3290. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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