Ezetimibe
This oral medication reduces cholesterol levels by blocking its absorption from food in the small intestine, lowering the amount of cholesterol that reaches the liver and bloodstream. It is often used alongside a statin for greater cholesterol reduction.
分子量
409.4000 g/mol
LogP
4.00
TPSA
60.80 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
二维结构
Cite this structure
Embed this structure
SMILES
O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1
InChI
InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
Molecular Formula
C24H21F2NO3
HBD / HBA
2 / 5
可旋转键数
6
重原子数
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This oral medication reduces cholesterol levels by blocking its absorption from food in the small intestine, lowering the amount of cholesterol that reaches the liver and bloodstream. It is often used alongside a statin for greater cholesterol reduction.
Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway of cholesterol biosynthesis. This reduces intracellular cholesterol, upregulates LDL receptor expression, and lowers circulating LDL cholesterol.
Yes, Ezetimibe is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1138. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 150311. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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