Fosaprepitant
This injectable prodrug is rapidly converted to aprepitant in the body to block substance P signaling in the brain, preventing the nausea and vomiting caused by chemotherapy. It is given intravenously before chemotherapy as part of a combination antiemetic regimen.
分子量
614.4000 g/mol
LogP
1.00
TPSA
124.00 Ų
Lipinski 五规则
不符合
治疗领域
作用机制
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
二维结构
Cite this structure
Embed this structure
SMILES
C[C@@H](O[C@H]1OCCN(Cc2nn(P(=O)(O)O)c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1
InChI
InChI=1S/C23H22F7N4O6P/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38)/t12-,19+,20-/m1/s1
Molecular Formula
C23H22F7N4O6P
HBD / HBA
3 / 15
可旋转键数
7
重原子数
41
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This injectable prodrug is rapidly converted to aprepitant in the body to block substance P signaling in the brain, preventing the nausea and vomiting caused by chemotherapy. It is given intravenously before chemotherapy as part of a combination antiemetic regimen.
Administered as an inactive precursor that is metabolically converted to its active form in the body. This prodrug design improves bioavailability, absorption, or targeted delivery compared to the active compound.
Yes, Fosaprepitant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1199324. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 135413538. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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