Hexobarbital
A short-acting barbiturate that was used as an intravenous anesthetic for induction of general anesthesia and for short surgical procedures. It produces rapid unconsciousness by enhancing GABA-mediated inhibition in the central nervous system. It has largely been replaced by safer intravenous anesthetic agents such as propofol.
分子量
236.2700 g/mol
LogP
1.50
TPSA
66.50 Ų
Lipinski 五规则
符合
作用机制
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
二维结构
Cite this structure
Embed this structure
SMILES
CN1C(=O)NC(=O)C(C)(C2=CCCCC2)C1=O
InChI
InChI=1S/C12H16N2O3/c1-12(8-6-4-3-5-7-8)9(15)13-11(17)14(2)10(12)16/h6H,3-5,7H2,1-2H3,(H,13,15,17)
Molecular Formula
C12H16N2O3
HBD / HBA
1 / 3
可旋转键数
1
重原子数
17
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A short-acting barbiturate that was used as an intravenous anesthetic for induction of general anesthesia and for short surgical procedures. It produces rapid unconsciousness by enhancing GABA-mediated inhibition in the central nervous system. It has largely been replaced by safer intravenous anesthetic agents such as propofol.
Selectively blocks angiotensin II type 1 (AT1) receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This results in vasodilation, reduced sodium retention, and decreased blood pressure.
Yes, Hexobarbital is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL7728. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 3608. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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