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Hexylcaine

CHEMBL1197 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
261.4 g/mol
LogP
3.6
Phase
4

A local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, used topically for anesthesia of mucous membranes in procedures such as endoscopy. It was used historically for topical anesthesia but has largely been replaced by agents with better-established safety profiles. Its mechanism of action is similar to other ester-type local anesthetics.

分子量

261.3600 g/mol

LogP

3.60

TPSA

38.30 Ų

Lipinski 五规则

符合

作用机制

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
CC(CNC1CCCCC1)OC(=O)c1ccccc1

                

                

                
                

                    
InChI

                    
InChI=1S/C16H23NO2/c1-13(12-17-15-10-6-3-7-11-15)19-16(18)14-8-4-2-5-9-14/h2,4-5,8-9,13,15,17H,3,6-7,10-12H2,1H3

                

                

                

                    
                    

                        
Molecular Formula

                        
C16H23NO2

                    

                    
                    

                        
HBD / HBA

                        
1 / 3

                    

                    
                    

                        
可旋转键数

                        
6

                    

                    
                    
                    

                        
重原子数

                        
19

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission, used topically for anesthesia of mucous membranes in procedures such as endoscopy. It was used historically for topical anesthesia but has largely been replaced by agents with better-established safety profiles. Its mechanism of action is similar to other ester-type local anesthetics.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Blocks voltage-gated sodium channels in nerve cell membranes, preventing the generation and conduction of nerve impulses. This produces reversible loss of sensation in the area of application.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Hexylcaine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1197.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 10770.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.