Idelalisib

CHEMBL2216870 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

415.4 g/mol

LogP

3.7

Phase

4

This oral targeted therapy inhibits phosphoinositide 3-kinase delta (PI3Kδ), an enzyme involved in the survival, proliferation, and migration of malignant B-cells. It is used to treat relapsed chronic lymphocytic leukemia (CLL) and follicular lymphoma. Serious side effects including liver toxicity, diarrhea, pneumonia, and infections require close monitoring.

分子量

415.4000 g/mol

LogP

3.70

TPSA

99.20 Å²

Lipinski 五规则

符合

治疗领域

Pancreatic Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1

InChI

InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1

Molecular Formula

C22H18FN7O

HBD / HBA

2 / 7

可旋转键数

5

重原子数

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

This oral targeted therapy inhibits phosphoinositide 3-kinase delta (PI3Kδ), an enzyme involved in the survival, proliferation, and migration of malignant B-cells. It is used to treat relapsed chronic lymphocytic leukemia (CLL) and follicular lymphoma. Serious side effects including liver toxicity, diarrhea, pneumonia, and infections require close monitoring.

Yes, Idelalisib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2216870. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 11625818. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C22H18FN7O
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.