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Ivosidenib

CHEMBL3989958 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
583.0 g/mol
LogP
3.4
Phase
4

This oral targeted therapy inhibits mutant IDH1 (isocitrate dehydrogenase 1) enzymes, which cause an abnormal buildup of 2-hydroxyglutarate that blocks cancer cell differentiation. It is used to treat acute myeloid leukemia (AML) with IDH1 mutations and cholangiocarcinoma with IDH1 mutations. It can induce differentiation syndrome as cancer cells mature, which requires prompt recognition and treatment.

分子量

583.0000 g/mol

LogP

3.40

TPSA

119.00 Ų

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
N#Cc1ccnc(N2C(=O)CC[C@H]2C(=O)N(c2cncc(F)c2)[C@H](C(=O)NC2CC(F)(F)C2)c2ccccc2Cl)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C28H22ClF3N6O3/c29-21-4-2-1-3-20(21)25(26(40)36-18-11-28(31,32)12-18)37(19-10-17(30)14-34-15-19)27(41)22-5-6-24(39)38(22)23-9-16(13-33)7-8-35-23/h1-4,7-10,14-15,18,22,25H,5-6,11-12H2,(H,36,40)/t22-,25-/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C28H22ClF3N6O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 9

                    

                    
                    

                        
可旋转键数

                        
7

                    

                    
                    
                    

                        
重原子数

                        
41

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
This oral targeted therapy inhibits mutant IDH1 (isocitrate dehydrogenase 1) enzymes, which cause an abnormal buildup of 2-hydroxyglutarate that blocks cancer cell differentiation. It is used to treat acute myeloid leukemia (AML) with IDH1 mutations and cholangiocarcinoma with IDH1 mutations. It can induce differentiation syndrome as cancer cells mature, which requires prompt recognition and treatment.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Ivosidenib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3989958.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 71657455.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.