Laropiprant
This prostaglandin D2 receptor antagonist was developed to reduce the uncomfortable skin flushing that commonly occurs when people take niacin (a cholesterol-lowering vitamin). It was used in combination with extended-release niacin to improve patient tolerability, but was ultimately withdrawn after clinical trials showed no cardiovascular benefit.
分子量
435.9000 g/mol
LogP
3.50
TPSA
84.80 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
二维结构
Cite this structure
Embed this structure
SMILES
CS(=O)(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3
InChI
InChI=1S/C21H19ClFNO4S/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26)/t13-/m1/s1
Molecular Formula
C21H19ClFNO4S
HBD / HBA
1 / 5
可旋转键数
5
重原子数
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This prostaglandin D2 receptor antagonist was developed to reduce the uncomfortable skin flushing that commonly occurs when people take niacin (a cholesterol-lowering vitamin). It was used in combination with extended-release niacin to improve patient tolerability, but was ultimately withdrawn after clinical trials showed no cardiovascular benefit.
Competitively binds to its target receptor without activating it, blocking the natural ligand from binding and preventing receptor-mediated signaling.
Yes, Laropiprant is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL426559. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 9867642. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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