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Levomilnacipran

CHEMBL99946 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
246.4 g/mol
LogP
1.4
Phase
4

An SNRI antidepressant with strong norepinephrine reuptake inhibition for major depressive disorder.

分子量

246.3500 g/mol

LogP

1.40

TPSA

46.30 Ų

Lipinski 五规则

符合

治疗领域

Pain Management Rheumatoid Arthritis Migraine Generalized Anxiety Disorder Systemic Lupus Erythematosus Stroke Major Depressive Disorder Chronic Pain

作用机制

Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.

Pharmacokinetics (PK)

Pharmacodynamics (PD)

机制

Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.

二维结构

SVG PNG

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SMILES

                    
CCN(CC)C(=O)[C@@]1(c2ccccc2)C[C@H]1CN

                

                

                
                

                    
InChI

                    
InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C15H22N2O

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
可旋转键数

                        
5

                    

                    
                    
                    

                        
重原子数

                        
18

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
An SNRI antidepressant with strong norepinephrine reuptake inhibition for major depressive disorder.

                        

                    

                    

                    

                    
                    

                        
                        

                            
Inhibits the reuptake of both serotonin and norepinephrine by blocking their respective presynaptic transporters. This dual mechanism enhances monoaminergic neurotransmission and produces antidepressant and analgesic effects.

                        

                    

                    

                    

                    

                        
                        

                            
Yes, Levomilnacipran is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL99946.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 6917779.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.