Lomitapide Mesylate

CHEMBL2105662 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

789.8 g/mol

LogP

—

Phase

4

The mesylate salt form of lomitapide, used to treat homozygous familial hypercholesterolemia. It is the pharmaceutical form approved for reducing dangerously elevated LDL cholesterol levels.

分子量

789.8000 g/mol

TPSA

124.00 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CS(=O)(=O)O.O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1

InChI

InChI=1S/C39H37F6N3O2.CH4O3S/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45;1-5(2,3)4/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49);1H3,(H,2,3,4)

Molecular Formula

C40H41F6N3O5S

HBD / HBA

3 / 12

可旋转键数

10

重原子数

55

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

The mesylate salt form of lomitapide, used to treat homozygous familial hypercholesterolemia. It is the pharmaceutical form approved for reducing dangerously elevated LDL cholesterol levels.

Yes, Lomitapide Mesylate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105662. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 11274333. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.

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结构

快速数据

分子式: C40H41F6N3O5S
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.