Lumateperone
An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar disorder. It has a unique pharmacological profile acting simultaneously on dopamine, serotonin, and glutamate receptors.
分子量
393.5000 g/mol
LogP
3.80
TPSA
26.80 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal …
二维结构
Cite this structure
Embed this structure
SMILES
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12
InChI
InChI=1S/C24H28FN3O/c1-26-14-15-28-21-11-13-27(16-20(21)19-4-2-5-22(26)24(19)28)12-3-6-23(29)17-7-9-18(25)10-8-17/h2,4-5,7-10,20-21H,3,6,11-16H2,1H3/t20-,21-/m0/s1
Molecular Formula
C24H28FN3O
HBD / HBA
- / 5
可旋转键数
5
重原子数
29
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar disorder. It has a unique pharmacological profile acting simultaneously on dopamine, serotonin, and glutamate receptors.
Blocks dopamine D2 receptors in the mesolimbic pathway, reducing excessive dopaminergic neurotransmission associated with psychotic symptoms. Many also antagonize serotonin 5-HT2A receptors, which may improve negative symptoms and reduce extrapyramidal side effects.
Yes, Lumateperone is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3306803. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 21302490. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-04.
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