Methapyrilene Fumarate
A fumarate form of methapyrilene with the same therapeutic properties. An antihistamine formerly used to treat allergy symptoms and as a sleep aid, this medication was withdrawn from the market after studies showed it caused liver cancer in animals.
分子量
871.0000 g/mol
TPSA
319.00 Ų
作用机制
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
二维结构
Cite this structure
Embed this structure
SMILES
CN(C)CCN(Cc1cccs1)c1ccccn1.CN(C)CCN(Cc1cccs1)c1ccccn1.O=C(O)/C=C/C(=O)O.O=C(O)/C=C/C(=O)O.O=C(O)/C=C/C(=O)O
InChI
InChI=1S/2C14H19N3S.3C4H4O4/c2*1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14;3*5-3(6)1-2-4(7)8/h2*3-8,11H,9-10,12H2,1-2H3;3*1-2H,(H,5,6)(H,7,8)/b;;3*2-1+
Molecular Formula
C40H50N6O12S2
HBD / HBA
6 / 20
可旋转键数
18
重原子数
60
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A fumarate form of methapyrilene with the same therapeutic properties. An antihistamine formerly used to treat allergy symptoms and as a sleep aid, this medication was withdrawn from the market after studies showed it caused liver cancer in animals.
Competitively blocks histamine H1 receptors on effector cells, preventing histamine-mediated vasodilation, increased vascular permeability, bronchoconstriction, and pruritus. First-generation agents also cross the blood-brain barrier, causing sedation.
Yes, Methapyrilene Fumarate is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3187246. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 6436730. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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