Metocurine
This semi-synthetic derivative of tubocurarine is a non-depolarizing neuromuscular blocking agent that paralyzes skeletal muscles by competing with acetylcholine at the neuromuscular junction, used during surgery and mechanical ventilation to achieve muscle relaxation. Its effects can be reversed with acetylcholinesterase inhibitors.
分子量
652.8000 g/mol
LogP
6.70
TPSA
55.40 Ų
Lipinski 五规则
不符合
作用机制
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
二维结构
Cite this structure
Embed this structure
SMILES
COc1ccc2cc1Oc1cc3c(cc1OC)CC[N+](C)(C)[C@H]3Cc1ccc(cc1)Oc1c(OC)c(OC)cc3c1[C@@H](C2)[N+](C)(C)CC3
InChI
InChI=1S/C40H48N2O6/c1-41(2)17-15-27-22-34(44-6)36-24-30(27)31(41)19-25-9-12-29(13-10-25)47-40-38-28(23-37(45-7)39(40)46-8)16-18-42(3,4)32(38)20-26-11-14-33(43-5)35(21-26)48-36/h9-14,21-24,31-32H,15-20H2,1-8H3/q+2/t31-,32+/m0/s1
Molecular Formula
C40H48N2O6+2
HBD / HBA
- / 6
可旋转键数
4
重原子数
48
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
This semi-synthetic derivative of tubocurarine is a non-depolarizing neuromuscular blocking agent that paralyzes skeletal muscles by competing with acetylcholine at the neuromuscular junction, used during surgery and mechanical ventilation to achieve muscle relaxation. Its effects can be reversed with acetylcholinesterase inhibitors.
Blocks neuromuscular transmission at the motor end plate by competing with acetylcholine for nicotinic receptor binding sites, producing skeletal muscle relaxation and paralysis.
Yes, Metocurine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1259. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 21233. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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