Nelarabine

CHEMBL1201112 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

297.3 g/mol

LogP

-0.7

Phase

4

This chemotherapy medication is used to treat T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that have not responded to or have relapsed after at least two previous treatments. It is given intravenously and works by interfering with the DNA of cancer cells, causing them to die.

分子量

297.2700 g/mol

LogP

-0.70

TPSA

149.00 Å²

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

COc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O

InChI

InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1

Molecular Formula

C11H15N5O5

HBD / HBA

4 / 9

可旋转键数

3

重原子数

21

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

This chemotherapy medication is used to treat T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that have not responded to or have relapsed after at least two previous treatments. It is given intravenously and works by interfering with the DNA of cancer cells, causing them to die.

Yes, Nelarabine is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1201112. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 3011155. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C11H15N5O5
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.