Nilotinib
A targeted therapy that blocks abnormal proteins driving certain leukemia cells to grow uncontrollably.
分子量
529.5000 g/mol
LogP
4.90
TPSA
97.60 Ų
Lipinski 五规则
符合
治疗领域
Pharmacokinetics (PK)
Pharmacodynamics (PD)
二维结构
Cite this structure
Embed this structure
SMILES
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1
InChI
InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
Molecular Formula
C28H22F3N7O
HBD / HBA
2 / 9
可旋转键数
6
重原子数
39
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
A targeted therapy that blocks abnormal proteins driving certain leukemia cells to grow uncontrollably.
Yes, Nilotinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL255863. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 644241. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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