Olmutinib

CHEMBL3786343 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

486.6 g/mol

LogP

4.7

Phase

4

A third-generation EGFR inhibitor that targets the T790M resistance mutation in non-small cell lung cancer, developed to treat patients who have progressed on earlier EGFR inhibitors. It selectively blocks mutant EGFR signaling while sparing the normal form of the receptor.

分子量

486.6000 g/mol

LogP

4.70

TPSA

111.00 Å²

Lipinski 五规则

符合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1

InChI

InChI=1S/C26H26N6O2S/c1-3-23(33)27-19-5-4-6-21(17-19)34-25-24-22(11-16-35-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

Molecular Formula

C26H26N6O2S

HBD / HBA

2 / 8

可旋转键数

7

重原子数

35

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A third-generation EGFR inhibitor that targets the T790M resistance mutation in non-small cell lung cancer, developed to treat patients who have progressed on earlier EGFR inhibitors. It selectively blocks mutant EGFR signaling while sparing the normal form of the receptor.

Yes, Olmutinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL3786343. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 54758501. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C26H26N6O2S

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.