Palovarotene

CHEMBL2105648 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

414.5 g/mol

LogP

6.8

Phase

4

A retinoic acid receptor gamma agonist used to reduce the formation of new bone in soft tissues in patients with fibrodysplasia ossificans progressiva, an extremely rare and disabling genetic disorder. It helps slow the progressive and irreversible ossification of muscles and connective tissues.

分子量

414.5000 g/mol

LogP

6.80

TPSA

55.10 Å²

Lipinski 五规则

符合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CC1(C)CCC(C)(C)c2cc(Cn3cccn3)c(/C=C/c3ccc(C(=O)O)cc3)cc21

InChI

InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+

Molecular Formula

C27H30N2O2

HBD / HBA

1 / 3

可旋转键数

5

重原子数

31

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A retinoic acid receptor gamma agonist used to reduce the formation of new bone in soft tissues in patients with fibrodysplasia ossificans progressiva, an extremely rare and disabling genetic disorder. It helps slow the progressive and irreversible ossification of muscles and connective tissues.

Yes, Palovarotene is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2105648. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 10295295. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C27H30N2O2
同义词: 1

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.