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Pemoline

CHEMBL1177 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
176.2 g/mol
LogP
0.9
Phase
4

A central nervous system stimulant formerly used to treat attention deficit hyperactivity disorder (ADHD), withdrawn from most markets due to serious liver toxicity. It worked by increasing dopamine activity but caused hepatic failure in some patients.

分子量

176.1700 g/mol

LogP

0.90

TPSA

64.70 Ų

Lipinski 五规则

符合

治疗领域

Type 2 Diabetes

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

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SMILES

                    
NC1=NC(=O)C(c2ccccc2)O1

                

                

                
                

                    
InChI

                    
InChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)

                

                

                

                    
                    

                        
Molecular Formula

                        
C9H8N2O2

                    

                    
                    

                        
HBD / HBA

                        
1 / 2

                    

                    
                    

                        
可旋转键数

                        
1

                    

                    
                    
                    

                        
重原子数

                        
13

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A central nervous system stimulant formerly used to treat attention deficit hyperactivity disorder (ADHD), withdrawn from most markets due to serious liver toxicity. It worked by increasing dopamine activity but caused hepatic failure in some patients.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Pemoline is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL1177.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 4723.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.