Pinacidil

CHEMBL1200338 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

263.3 g/mol

LogP

—

Phase

4

Pinacidil is a potassium channel opener of the cyanoguanidine class that activates ATP-sensitive potassium (K-ATP) channels in vascular smooth muscle, causing hyperpolarization, relaxation, and vasodilation. It was investigated as an antihypertensive agent and has been used experimentally in cardioprotection research, though it never achieved widespread clinical use.

分子量

263.3400 g/mol

TPSA

74.10 Å²

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

CC(N/C(=N\C#N)Nc1ccncc1)C(C)(C)C.O

InChI

InChI=1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2

Molecular Formula

C13H21N5O

HBD / HBA

3 / 4

可旋转键数

5

重原子数

19

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Pinacidil is a potassium channel opener of the cyanoguanidine class that activates ATP-sensitive potassium (K-ATP) channels in vascular smooth muscle, causing hyperpolarization, relaxation, and vasodilation. It was investigated as an antihypertensive agent and has been used experimentally in cardioprotection research, though it never achieved widespread clinical use.

Yes, Pinacidil is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1200338. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 55329. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C13H21N5O

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.