Podofilox
Podofilox (podophyllotoxin) is an antimitotic agent derived from the mayapple plant that inhibits microtubule assembly by binding to tubulin, thereby arresting cell division at metaphase and inducing apoptosis in rapidly dividing cells. It is used topically for the treatment of external genital and perianal warts (condylomata acuminata) caused by human papillomavirus.
分子量
414.4000 g/mol
LogP
2.00
TPSA
92.70 Ų
Lipinski 五规则
符合
治疗领域
作用机制
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
二维结构
Cite this structure
Embed this structure
SMILES
COc1cc([C@@H]2c3cc4c(cc3[C@H](O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1OC
InChI
InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
Molecular Formula
C22H22O8
HBD / HBA
1 / 8
可旋转键数
4
重原子数
30
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Podofilox (podophyllotoxin) is an antimitotic agent derived from the mayapple plant that inhibits microtubule assembly by binding to tubulin, thereby arresting cell division at metaphase and inducing apoptosis in rapidly dividing cells. It is used topically for the treatment of external genital and perianal warts (condylomata acuminata) caused by human papillomavirus.
Applied directly to the skin or mucous membranes, where it exerts its therapeutic effect locally at the site of application with minimal systemic absorption.
Yes, Podofilox is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL61. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 10607. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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