Ponatinib

CHEMBL1171837 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

532.6 g/mol

LogP

4.1

Phase

4

A targeted therapy used to treat certain types of leukemia, particularly chronic myeloid leukemia and acute lymphoblastic leukemia, especially in patients whose cancer carries a specific genetic mutation called T315I that makes other similar medications ineffective. It works by blocking proteins that drive the uncontrolled growth of leukemia cells.

分子量

532.6000 g/mol

LogP

4.10

TPSA

65.80 Å²

Lipinski 五规则

符合

治疗领域

Ovarian Cancer Pancreatic Cancer Bladder Cancer Thyroid Cancer Non-Small Cell Lung Cancer Lymphoma Breast Cancer Prostate Cancer Colorectal Cancer Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12

InChI

InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)

Molecular Formula

C29H27F3N6O

HBD / HBA

1 / 8

可旋转键数

6

重原子数

39

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

A targeted therapy used to treat certain types of leukemia, particularly chronic myeloid leukemia and acute lymphoblastic leukemia, especially in patients whose cancer carries a specific genetic mutation called T315I that makes other similar medications ineffective. It works by blocking proteins that drive the uncontrolled growth of leukemia cells.

Yes, Ponatinib is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL1171837. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 24826799. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C29H27F3N6O
同义词: 1

外部链接

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.