Prazepam
Prazepam is a long-acting benzodiazepine anxiolytic that potentiates the inhibitory neurotransmitter GABA at the GABA-A receptor by allosterically enhancing chloride ion conductance, producing anxiolytic, sedative, anticonvulsant, and muscle relaxant effects. It serves as a prodrug, being converted to the active metabolite desmethyldiazepam (nordazepam), and is used for the treatment of anxiety disorders.
分子量
324.8000 g/mol
LogP
3.60
TPSA
32.70 Ų
Lipinski 五规则
符合
作用机制
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
Pharmacokinetics (PK)
Pharmacodynamics (PD)
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
二维结构
Cite this structure
Embed this structure
SMILES
O=C1CN=C(c2ccccc2)c2cc(Cl)ccc2N1CC1CC1
InChI
InChI=1S/C19H17ClN2O/c20-15-8-9-17-16(10-15)19(14-4-2-1-3-5-14)21-11-18(23)22(17)12-13-6-7-13/h1-5,8-10,13H,6-7,11-12H2
Molecular Formula
C19H17ClN2O
HBD / HBA
- / 2
可旋转键数
3
重原子数
23
No targets recorded
Target interaction data is not yet available for this drug.
No interactions recorded
Drug interaction data is not yet available for this compound.
No side effects recorded
Side effect data is not yet available for this drug.
常见问题
Prazepam is a long-acting benzodiazepine anxiolytic that potentiates the inhibitory neurotransmitter GABA at the GABA-A receptor by allosterically enhancing chloride ion conductance, producing anxiolytic, sedative, anticonvulsant, and muscle relaxant effects. It serves as a prodrug, being converted to the active metabolite desmethyldiazepam (nordazepam), and is used for the treatment of anxiety disorders.
Reduces skeletal muscle tone and spasm through central or peripheral mechanisms, typically by modulating spinal reflexes, enhancing inhibitory neurotransmission, or blocking neuromuscular transmission.
Yes, Prazepam is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.
References & Data Sources
- ChEMBL — European Bioinformatics Institute (EBI). CHEMBL969. Open-access bioactivity database.
- PubChem — National Center for Biotechnology Information (NCBI). CID 4890. Chemical information database.
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.
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