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Rezafungin

CHEMBL3989945 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
1226.4 g/mol
LogP
2.9
Phase
4

Rezafungin is a novel long-acting echinocandin antifungal agent that inhibits beta-1,3-D-glucan synthase, an enzyme essential for fungal cell wall biosynthesis, disrupting cell wall integrity and causing osmotic instability and fungal cell death. Its extended half-life allows once-weekly intravenous dosing, distinguishing it from other echinocandins, and it has activity against Candida species including fluconazole-resistant strains and Pneumocystis jirovecii.

分子量

1226.4000 g/mol

LogP

2.90

TPSA

366.00 Ų

Lipinski 五规则

不符合

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
Embed this structure

                        

                        

                            
                            
                        

                    

                

                

                
                

                    
SMILES

                    
CCCCCOc1ccc(-c2ccc(-c3ccc(C(=O)N[C@H]4C[C@@H](O)[C@@H](OCC[N+](C)(C)C)NC(=O)[C@@H]5[C@@H](O)[C@@H](C)CN5C(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@H](O)[C@@H](O)c5ccc(O)cc5)NC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@H]([C@@H](C)O)NC4=O)cc3)cc2)cc1

                

                

                
                

                    
InChI

                    
InChI=1S/C63H84N8O17/c1-8-9-10-28-87-45-25-21-40(22-26-45)38-13-11-37(12-14-38)39-15-17-42(18-16-39)56(80)64-46-31-48(76)61(88-29-27-71(5,6)7)68-60(84)52-53(77)34(2)32-70(52)63(86)50(36(4)73)66-59(83)51(55(79)54(78)41-19-23-43(74)24-20-41)67-58(82)47-30-44(75)33-69(47)62(85)49(35(3)72)65-57(46)81/h11-26,34-36,44,46-55,61,72-73,75-79H,8-10,27-33H2,1-7H3,(H5-,64,65,66,67,68,74,80,81,82,83,84)/p+1/t34-,35+,36+,44+,46-,47-,48+,49-,50-,51-,52-,53-,54-,55-,61+/m0/s1

                

                

                

                    
                    

                        
Molecular Formula

                        
C63H85N8O17+

                    

                    
                    

                        
HBD / HBA

                        
13 / 17

                    

                    
                    

                        
可旋转键数

                        
18

                    

                    
                    
                    

                        
重原子数

                        
88

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
Rezafungin is a novel long-acting echinocandin antifungal agent that inhibits beta-1,3-D-glucan synthase, an enzyme essential for fungal cell wall biosynthesis, disrupting cell wall integrity and causing osmotic instability and fungal cell death. Its extended half-life allows once-weekly intravenous dosing, distinguishing it from other echinocandins, and it has activity against Candida species including fluconazole-resistant strains and Pneumocystis jirovecii.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Rezafungin is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL3989945.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 78318119.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.