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Roflumilast

CHEMBL193240 Phase 4 已批准 Small molecule
Half-Life
—
Bioavailability
—
Protein Binding
—
Molecular Weight
403.2 g/mol
LogP
4.6
Phase
4

A phosphodiesterase-4 inhibitor used to reduce the frequency of flare-ups in severe chronic obstructive pulmonary disease by decreasing airway inflammation. It is taken as a daily oral tablet and is intended as an add-on therapy for patients with frequent COPD exacerbations.

分子量

403.2000 g/mol

LogP

4.60

TPSA

60.50 Ų

Lipinski 五规则

符合

治疗领域

Cardiovascular Disease Asthma Chronic Obstructive Pulmonary Disease Alzheimer's Disease Schizophrenia Psoriasis Obesity Lymphoma Type 2 Diabetes Major Depressive Disorder Atopic Dermatitis Heart Failure Leukemia

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

SVG PNG

Cite this structure


                        

                            
                            
                        

                    

                


                
                

                    

                    

                        
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SMILES

                    
O=C(Nc1c(Cl)cncc1Cl)c1ccc(OC(F)F)c(OCC2CC2)c1

                

                

                
                

                    
InChI

                    
InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)

                

                

                

                    
                    

                        
Molecular Formula

                        
C17H14Cl2F2N2O3

                    

                    
                    

                        
HBD / HBA

                        
1 / 6

                    

                    
                    

                        
可旋转键数

                        
7

                    

                    
                    
                    

                        
重原子数

                        
26

                    

                    
                

            


            
            

                
                


    
    
        
    
    
    
No targets recorded

    
    
Target interaction data is not yet available for this drug.

    



                
            


            
            

                
                


    
    
        
    
    
    
No interactions recorded

    
    
Drug interaction data is not yet available for this compound.

    



                
            


            
            

                
                


    
    
        
    
    
    
No side effects recorded

    
    
Side effect data is not yet available for this drug.

    



                
            


            
            
            

                
常见问题

                

                    
                    

                        
                        

                            
A phosphodiesterase-4 inhibitor used to reduce the frequency of flare-ups in severe chronic obstructive pulmonary disease by decreasing airway inflammation. It is taken as a daily oral tablet and is intended as an add-on therapy for patients with frequent COPD exacerbations.

                        

                    

                    

                    

                    

                    

                    

                        
                        

                            
Yes, Roflumilast is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

                        

                    

                

            

            

            
            

            
            

            
            
{# References & Data Sources section for drug detail pages.
   Renders standard pharmacological database links plus the drug's data_sources field. #}


    
References & Data Sources

    
    
        
        
  • 
            
            
                ChEMBL — European Bioinformatics Institute (EBI).
                CHEMBL193240.
                Open-access bioactivity database.
            
        
    • 
        
        
        
  • 
            
            
                PubChem — National Center for Biotechnology Information (NCBI).
                CID 449193.
                Chemical information database.
            
        
    • 
        
        
        
        
    

    
Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.




        


        
        
    


    



    
医疗免责声明

    

        This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.
    

    

        Data sources:
        ChEMBL,
        PubChem,
        DailyMed.