Roxadustat

CHEMBL2338329 Phase 4 已批准 Small molecule

Half-Life

—

Bioavailability

—

Protein Binding

—

Molecular Weight

352.3 g/mol

LogP

3.4

Phase

4

Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) used for the treatment of anemia associated with chronic kidney disease. By inhibiting prolyl hydroxylase domain enzymes, it stabilizes HIF-alpha subunits, stimulating erythropoietin production and improving iron absorption and mobilization. Unlike erythropoiesis-stimulating agents, it is orally administered and has demonstrated cardiovascular benefits in clinical trials.

分子量

352.3000 g/mol

LogP

3.40

TPSA

109.00 Å²

Lipinski 五规则

符合

治疗领域

Cardiovascular Disease Generalized Anxiety Disorder Chronic Kidney Disease Heart Failure

Pharmacokinetics (PK)

Pharmacodynamics (PD)

二维结构

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SMILES

Cc1nc(C(=O)NCC(=O)O)c(O)c2ccc(Oc3ccccc3)cc12

InChI

InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)

Molecular Formula

C19H16N2O5

HBD / HBA

3 / 6

可旋转键数

5

重原子数

26

No targets recorded

Target interaction data is not yet available for this drug.

No interactions recorded

Drug interaction data is not yet available for this compound.

No side effects recorded

Side effect data is not yet available for this drug.

常见问题

Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) used for the treatment of anemia associated with chronic kidney disease. By inhibiting prolyl hydroxylase domain enzymes, it stabilizes HIF-alpha subunits, stimulating erythropoietin production and improving iron absorption and mobilization. Unlike erythropoiesis-stimulating agents, it is orally administered and has demonstrated cardiovascular benefits in clinical trials.

Yes, Roxadustat is an approved drug. It has reached clinical phase 4. It is classified as a Small molecule.

{# References & Data Sources section for drug detail pages. Renders standard pharmacological database links plus the drug's data_sources field. #}

References & Data Sources

ChEMBL — European Bioinformatics Institute (EBI). CHEMBL2338329. Open-access bioactivity database.
PubChem — National Center for Biotechnology Information (NCBI). CID 11256664. Chemical information database.

Data aggregated from publicly available pharmacological databases. Last updated 2026-03-28.

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结构

快速数据

分子式: C19H16N2O5

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医疗免责声明

This content is for educational and informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making medication decisions.

Data sources: ChEMBL, PubChem, DailyMed.